The intronic angiotensin II type 2 receptor gene polymorphism 1675 G/A modulates receptor protein expression but not mRNA splicing
نویسندگان
چکیده
Christina Warnecke, Peter Mugrauer, Daniel Sürder, Jeanette Erdmann, Carola Schubert, Vera Regitz-Zagrosek Cardiovascular Disease in Women, Center for Cardiovascular Research, Charité University Medicine Berlin, and German Heart Institute, Berlin, Germany; Medical Clinic IV/Renal Research Laboratories, University Erlangen-Nürnberg, Erlangen, Germany; Clinic for Internal Medicine 2, University of Schleswig-Holstein, Luebeck, Germany
منابع مشابه
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The X-linked ANG II type 2 receptor (AT2) is supposed to be involved in cardiovascular disorders. Two studies associated the A allele of the AT2 gene polymorphism (PM) 1675 G/A with left ventricular hypertrophy in men and coronary ischemia in women. Because the PM is located in the short intron 1 of the AT2 gene within a sequence motif similar to the splice branch site consensus, we tested whet...
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OBJECTIVES Our study goal was to analyze whether gene variants of angiotensin II type 2-receptor (AT2-R) modulate the effects of angiotensin II on the left ventricle (LV). BACKGROUND Experimental data suggest that angiotensin II modifies ventricular growth responses via angiotensin II type 1-receptors (AT1-R) and AT2-R. METHODS In 120 white, young male subjects with normal or mildly elevate...
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Objective(s): Considering the lack of information, the effects of mild endurance exercise plus blood flow restriction (BFR) on electrocardiographic parameters, hypertrophy index, and expression of angiotensin II receptors type 1 (AT1R) and type 2 (AT2R) and apelin receptor (APJ) were assessed in hearts of old male rats.Materials and Methods: Animal were grouped as control (CTL), Sham (Sh), lowe...
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تاریخ انتشار 2005